Various nutrition guidelines recommend increased protein supplementation with continuous kidney replacement therapy (CKRT). Recent EFFORT Protein trial, international multicenter single-blinded randomized trial in the intensive care unit supplying usual protein dose vs higher dose over 2.2g/kg/day. Subgroup analysis suggested an interaction between protein dose and patients with acute kidney injury (stage 1–3) and high SOFA score (≥9) upon admission on both time-todischarge-alive (appendix p 15) and 60-day mortality (appendix p 16), favoring the usual protein dose.
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Lee et al. (2024) studied this question.
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