Seronegative lupus nephritis (LN) has been used to describe patients with typical renal histology of LN but without clinical nor serological evidence of systemic lupus erythematosus (SLE). Possible causes include hepatitis B and C, cryoglobulinemic GN, infection associated GN, C1q nephropathy, IgA nephropathy or idiopathic. Furthermore, the possibility of seronegative SLE should not be ruled out, implying that SLE diagnosis may occur even up to 10 years after histopathological findings. We present a seronegative patient with proliferative LN pattern where the diagnosis and the treatment are a challenge.
No takes yet. Share an insight, caveat, or question.
carvajal et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: