Mesoamerican Nephropathy (MeN) is an epidemic of chronic kidney disease (CKD) in Mesoamerica that primarily affects young men working in sugar cane agriculture. The etiology of MeN remains unclear and may be linked to recurrent acute kidney injury (AKI) leading to CKD driven by heat stress. Individuals with MeN commonly present with hyperuricemia. Decreased urine levels of the purine breakdown metabolites inosine, guanosine, and adenosine are associated with other forms of AKI and are of particular interest in the context of MeN given their subsequent breakdown product uric acid is characteristically high in MeN.
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Santos et al. (2024) studied this question.
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