Renal interstitial fibrosis is a common response to injury or chronic damage to the kidney and is a major contributor to the progression of chronic kidney diseases. Effective treatment strategies for renal interstitial fibrosis are not yet firmly established, making it a challenging aspect of managing kidney diseases. Long non-coding RNAs (lncRNAs) are non-protein encoding RNAs composed of more than 200 nucleotides. They play roles in diverse physiological and pathological processes, including transcriptional regulation, epigenetic modification, cellular signaling, and the development of various diseases.
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Ishimoto et al. (2024) studied this question.
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