WCN24-69 Release of uremic retention solutes from protein binding by hypertonic predilution hemodiafiltration: a novel therapeutic approach

Introduction: Methods: The protein-bound fraction of phenylacetic acid, indoxyl sulfate and p-cresyl sulfate was significantly decreased from 59.4±3.4%, 95.7±0.6%, 96.9±1.5% to 36.4±3.7%, 87.8±0.6% and 90.8±1.3% respectively. The percentage of phenylacetic acid, indoxyl sulfate and p-cresyl sulfate released from protein was 23.0±5.7%, 7.9±1.1% and 6.1±0.2%. The clearance during in-vitro dialysis was increased by 13.1±3.6 %, 68.8±15.1 % and 53.6±10.2 %, respectively. There was no difference in NaCl concentrations at the outlet of the dialyser using isotonic and hypertonic solutions. I have no potential conflict of interest to disclose.