Shiga Toxin producing Escherichia coli (STEC)-associated hemolytic uremic syndrome (HUS), defined as typical, is the most common cause of acute renal failure in children. Atypical HUS (aHUS) is usually caused by uncontrolled complement activation, secondary to a dysregulation of the alternative pathway most frequently due to genetic variants in complement regulating proteins.
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Marina et al. (2024) studied this question.
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