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This abstract is part of my collaboration with my mentor in the ISN mentorship program. Diabetic nephropathy represents a significant contributor to end-stage kidney disease (ESKD). Among the numerous cytokines implicated in the development of diabetic nephropathy, one of paramount importance is transforming growth factor beta-1 (TGF-β1). Its primary function lies in facilitating the deposition of extracellular matrix. Diabetic nephropathy typically presents with elevated renal levels of TGF-β1, and the measurement of its urinary excretion can serve as a valuable indicator for predicting outcomes.
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Kulkarni et al. (2024) studied this question.
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