Wcn24-2653 Inmmunoflorescence From Paraffin-Embedded Sample in Monoclonal Gammopathies. Case Report

The technique of immunofluorescence in fresh renal tissue, without fixation and frozen (IF-F), has been the gold standard for over 60 years for histological studies to detect immune complexes. However, there is a complementary technique known as immunofluorescence in fixed and paraffin-embedded sections (IF-P), which has shown greater sensitivity than IF-F in detecting immunoglobulin deposits. IF-P proves useful when the sample for IF-F is inadequate or unavailable. We report a case where the use of IF-P was crucial for diagnosing renal significant monoclonal gammopathy (RSMG).