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Crystal storing histiocytosis (CSH) is a rare morphologic manifestation of monoclonal gammopathy of renal significance (MGRS) in which monoclonal crystals of various geometric shapes collect within histiocytes and are deposited in various organs like kidneys, bone marrow, lungs, liver, stomach, spleen, skin and cornea. Usually kappa subtype of monoclonal crystals, in the renal interstitium or glomerular capillary walls have been described in the literature. We present a case of CSH with lambda monoclonal crystals involving the proximal renal tubules causing light chain tubulopathy in a patient with chronic kidney disease with sub-nephrotic range proteinuria.
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Gautam et al. (2024) studied this question.
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