Wcn24-1335 Pirfenidone Downregulates Renal Fibrogenesis and Inflammation Slowing CKD Progression in an Experimental Model of Hypertensive Nephrosclerosis

Chronic kidney disease (CKD) is characterized by progressive loss of kidney function. Several factors contribute to its development, including clinical conditions such as hypertension and diabetes. After an initial insult, disease progression is characterized by changes in renal hemodynamics and local inflammation, resulting in tissue fibrosis. Therefore, the participation of cellular and inflammatory mechanisms in the process has been intensely investigated. The lack of an effective treatment to slow CKD progression or reverse the established damage led to the search for new strategies.