Title: SYLVIAN FISSURE AND INSULAR LOBE DEPTH IN NORMAL ‎PREGNANCY VERSUS INTRAUTERINE GROWTH RESTRICTION IN ‎SEVERE PRE-ECLAMPSIA

Definitions of pre-eclampsia have varied throughout the times. ‎Improved understanding of the pathogenesis of pre-eclampsia has influenced the ‎definitions. Pre-eclampsia is a pregnancy specific condition diagnosed when ‎blood pressure is elevated above 140 mmHg systolic and/or 90 mmHg diastolic ‎and proteinuria over 0.3 mg per day after 20+0 weeks of gestation. Pre-eclampsia‎is commonly divided into early- and late-onset disease and preterm and term ‎subtypes based on the time of delivery or time of the diagnosis. The American ‎College of Obstetricians and Gynecologists (ACOG) proposed, in the Task Force ‎on Hypertension in gestation recommendations that, in the absence of proteinuria, ‎pre-eclampsia could be diagnosed when newly diagnosed hypertension occurs in ‎association with thrombocytopenia, impaired liver function, new development of ‎renal insufficiency, pulmonary oedema, or new onset cerebral or visual ‎disturbances. The Australasian Society for the Study of Hypertension and the ‎Society of Obstetricians and Gynaecologists of Canada have adopted even ‎broader definitions and include fetal features, such as fetal growth restriction, in ‎the definitions. ‎