Hepatitis B Surface Antigen Seroconversion Developed with Tenofovir Disoproxil Fumarate: HIV/HBV Case Report and Literature Review

Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfections are important health problems worldwide and in our country.While acute HBV infections are relatively rare in patients with HIV infection, the chronicity rate is more prevalent in HIV-HBV co-infections.A 49-year-old male patient who was admitted with acute HBV symptoms is presented in this case.During the investigation of the cause of hepatitis, HIV infection was also detected, and emtricitabine + tenofovir disoproxil fumarate + dolutegravir treatment was initiated.While the patient developed a virological and immunological response to HIV infection, hepatitis B surface antigen seroconversion also occurred.This case report aimed to draw attention to HIV-acute HBV coinfection and analyze HBV reactivation and immune reconstruction syndrome in HIVpositive individuals.It is obvious that there is a need for research on the prevalence, risk factors, and prognosis of co-infection in our country.