Incidence of Metabolic Syndrome among Adults on First-Line Highly Active Antiretroviral Therapy Regimens in Malaysia

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Introduction: Despite the established effectiveness of highly active antiretroviral therapy (HAART) in reducing HIV-related morbidity and mortality, concerns are rising regarding the emergence of metabolic syndrome (MetS).However, there is inadequate evidence regarding the incidence of MetS among adults starting firstline HAART regimens in Malaysia.Objectives: This study was conducted to determine overall incidence of MetS in HIV patients on first-line HAART regimens and to assess the association between first-line HAART and incidence of MetS at 6-month and 9-month follow-ups among studied subjects.Methodology: This was a prospective cohort study involving adult patients (≥ 18 years old) diagnosed with HIV from January 2023 till May 2023 and on first-line HAART regimen with or without integrase strand transfer inhibitor (INSTI) for at least 6 months undergoing followup at infectious disease (ID) clinic at a tertiary Malaysian hospital.The study subjects were screened and recruited using purposive sampling after being selectively allocated into 2 groups according to inclusion and exclusion criteria.The patients' profiles were screened via the electronic