Study of Fatty Acid Binding Protein 4 (FABP4) levels in Patients with Beta-thalassemia and its Related Complications...

Introduction: Due to iron overload, patients with beta-thalassemia may experience complications. Several adipokines have been proposed as potential contributors to the development of beta-thalassemia complications. One of the adipokines, fatty acid-binding protein 4 (FABP4), connects various elements of the inflammatory and metabolic pathways. Aim of the study: This study assessed B-thalassemia patients' serum (FABP4) levels and linked them to complications related to thalassemia. Subjects and Methods: There were fifty adult participants in this cross-sectional study. A thorough clinical examination and medical history were completed. Every participant had their serum levels of fatty acid binding protein four measured.Results: According to our findings, 24% of patients had HCV +ve, 36% had gall bladder stones, and 44% had elevated liver enzymes. Patients with serum ferritin levels greater than 2500 ng/ml and FABP4 level did not significantly correlate (p value < 0.05).Conclusions: Patients with beta thalassemia had elevated liver enzymes, GB stones, and a high prevalence of HCV +ve. There was no discernible relationship between patients with serum ferritin levels higher than 2500 ng/ml and FABP4 level.