Editorial review highlights advancements in ancillary molecular diagnostics across diverse pathologies, emphasizing improved patient management through targeted therapies.
Dear Readers, Foremost, I would like to inform you that recently, we have detailed the aims and scope of IJPM so that we receive manuscripts that seem to be in the purview of the journal. Hopefully, this would avoid and reduce the number of unrelated manuscripts submitted to the journal. I insist that the authors carefully read the section and the instructions before they submit a manuscript. Publication of original articles based on well-designed studies that intend to showcase recent updates and concepts that enhance our understanding and influence patient management receive priority. I welcome you to read the April–June issue of IJPM. There is a good admixture of review articles, followed by original studies reflecting the value addition of ancillary techniques, such as next-generation sequencing (NGS), stem cells, newer immunohistochemical markers, and timeless clinicopathological studies. The opening review article by Deshpande et al. is an account of an ongoing educational legacy, The Teaching Pathologist's Association of Mumbai. The authors have described the initiation by two renowned Indian pathologists, Dr V. R. Khanolkar and Dr. P. V. Gharpure, and subsequent growth of this association, which can be an inspiring model for other regions to follow. In another stimulating review article, Mallika et al. have described the value of analyzing and targeting cancer stem cells for developing improved targeted therapies for the management of cancer patients.[1] Das et al. have reported a correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-naïve celiac disease.[2] Balta et al. have shown the prognostic and predictive value addition of NGS in the management of prostate carcinoma patients.[3] Günler et al. have described an association between cribriform comedo-type adenocarcinoma of the colon with certain aggressive clinicopathological parameters.[4] Koyuncuer et al. have described the value of INSM1 as a relatively new immunohistochemical antibody marker in diagnosing well-differentiated neuroendocrine tumors of the appendix.[5] Aytekin et al. have described congenital abnormalities of the kidney and urinary tract in autopsies over 22 years at their institution.[6] Cao et al. have reported the key genes involved in the pathogenesis of Kawasaki disease.[7] Parameshwar et al. have elaborated upon the clinicopathological spectrum of a relatively uncommon mesenchymal tumor, namely, a phosphaturic mesenchymal tumor.[8] In another study, Appasani et al. have reported the clinicopathological spectrum of 34 central nervous system germ cell tumors, while Fathaddin has described a spectrum of cutaneous lesions in patients with chronic kidney.[9] Thakur et al. have described the importance of preoperative evaluation of red blood cell distribution width as a promising biomarker for discriminating between benign and malignant breast tumors and assessing breast cancer activity.[10] Besides various other interesting original articles, there are brief communications, including on rare tumors, along with interesting case reports and letters. I wish you happy reading and hope to receive more original articles, including from the subcontinent that showcases the much-needed high-quality data from this part of the world.
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Bharat Rekhi (2024) studied this question.
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