Changing Trends in Antimicrobial Resistance of Gram- Negative Uropathogens Over a Period of Two Years in a Tertiary Care Centre

Antimicrobial Resistance (AMR) poses a major threat to human health around the world.This study aimed to assess the of Antimicrobial Resistance (AMR) trends of common gram negative uropathogens over 2 years among patients with UTI in a tertiary care centre.A retrospective analysis was performed using patients medical records and institutional database over a 2 years period (2019)(2020)(2021).Changing trends in antimicrobial resistance of gram-negative uropathogens and risk factors of UTI were identified.From a total of 184 patients, the most common organisms were Escherichia coli (13.04%),Enterobacter cloacae (2.17%) and others (8.6%).Female gender (59.24%), age group of 60-79 years (55.43%),history of catheterisation (21.7%) & UTI (18.47%), comorbidities like diabetes mellitus (37.2%) & hypertension (30.43%) were found to be the major risk factors.Ceftriaxone & Cotrimoxazole showed increase in resistance for E. coli over 2 years.Antimicrobials such as piperacillin & tazobactam and Amikacin shows increasing trend of resistance to Pseudomonas aeruginosa over 2019-2021.Our study shows the trends of antimicrobial resistance of Escherichia coli and Pseudomonas aeruginosa.Knowledge of this trends will help clinicians to choose the right empirical antibiotic treatment.Antimicrobial Stewardship Programs (ASPs) should be implemented which will help curb inappropriate antibiotic use in our region.