Randomized double-blind trial reports maternal Tdap safety and neonatal pertussis toxin antibody responses in pregnant women, highlighting strategies against infant morbidity.
While maternal pertussis vaccination is a strategy to reduce infant morbidity, safety and immunogenicity data are limited in sub-Saharan Africa. We aimed to evaluate the safety of a single dose of tetanus, diphtheria and acellular pertussis vaccine (Tdap) vaccine compared to tetanus and diphtheria vaccine (Td) vaccine in pregnant women in Bamako, Mali and to assess the pertussis toxin (PT) antibody response at birth.
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Haidara et al. (2024) studied this question.
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