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March 28, 2024Neurology Neuroimmunology & NeuroinflammationOpen Access

Disease-Modifying Treatments for Multiple Sclerosis Affect Measures of Cellular Immune Responses to EBNA-1 Peptides

Lara S. Dungan Jean Dunne Michael Savio Marianna Kalaszi Matt McElheron Yvonne Lynagh Kate O’Driscoll Carmel Roche Ammara Qureshi Brendan Crowley Niall Conlon Hugh Kearney

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Abstract

Epstein-Barr virus (EBV) has been strongly implicated in the pathogenesis of multiple sclerosis (MS). Despite this, there are no routinely used tests to measure cellular response to EBV. In this study, we analyzed the cellular response to EBV nuclear antigen-1 (EBNA-1) in people with MS (pwMS) using a whole blood assay.

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Dungan et al. (2024) studied this question.

synapsesocial.com/papers/68e71fddb6db6435876995ea https://doi.org/10.1212/nxi.0000000000200217

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Heightened Epstein-Barr virus immunity and potential cross-reactivities in multiple sclerosis2024 · 24 citations
2Multiple molecular mimics in Epstein Barr Nuclear Antigen-1, and the pathogenesis of multiple sclerosisOriginal Research · 2026 · 8 citations
3Enhanced and cross-reactive in vitro memory B cell response against Epstein-Barr virus nuclear antigen 1 in multiple sclerosis2024 · 16 citations
4Serologic Response to the Epstein-Barr Virus Peptidome and the Risk for Multiple Sclerosis2024 · 38 citations
5The level of anti-viral antigen-specific antibodies to EBNA-1 in the serum of ms patients does not depend on the severity of the disease2024

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Proinflammatory Epstein–Barr Virus Antibody Functions Track with Disease Activity in Multiple Sclerosis2026
Cytokine Signatures Induced by Epstein-Barr Virus Antigens in Multiple Sclerosis: Elucidating the Role of B-Cell and T-Cell Hyperactivation in Disease Relapse2025
The Level of Anti-Viral Antigen-Specific Antibodies to EBNA-1 in the Serum of MS Patients Does not Depend on the Severity of the Disease2024

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