Patient Adherence to a Digital Real-World GLP-1 RA-Supported Weight-Loss Program in the UK: A Retrospective Cohort Study

This study aimed to assess why and at what point along the care journey patients tend to discontinue a real world GLP1 RA-supported Digital Weight-Loss Service (DWLS) for women in the UK. To achieve these objectives, a cohort of 8294 patients was retrospectively analyzed, using both descriptive statistics and correlation tests. Mean adherence to the program was 183.1 (±148.9) days and the most common reasons for discontinuation were program cost (38.7%), dissatisfaction with results (16.8%), intolerable side effects (15.4%), attainment of one's weight-loss goal (7.3%) and temporary pause/holidays (5.6%). Patients who were older, Caucasian and overweight tended to adhere to the program for a statistically significantly longer period than their younger, non-Caucasian and higher BMI-class peers. This study provides important foundational insights to the scarce literature on real world GLP-1 RA-supported DWLSs, which are becoming increasingly popular in the obesity epidemic.