Emerging Strategies for Optimizing Cell‐Derived Decellularized Extracellular Matrix Scaffolds in Tissue Engineering

As an ideal biological scaffold, cell‐derived decellularized extracellular matrix (dECM) attracts increasing attention and is prepared and studied for tissue engineering. However, a few barriers prevent its extensive clinical usage, indicating that it requires further optimization. This review starts with a brief introduction to the benefits and limitations of dECM as a biomaterial. Then, it provides a novel perspective summarizing and describing methods for dECM optimization, delineating strategies to optimize regular cell‐derived dECM sheet preparation and additional biochemical or mechanophysical procedures to further modify the scaffold. These innovative approaches equip engineered biomaterials based on cell‐derived dECMs with key properties and functionalities, thus providing a great opportunity for their broader future therapeutic applications. Finally, several ideas and directions for future development are also prospected.