⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

March 27, 2024International Journal of Molecular SciencesOpen Access

Integrated Computational Approaches for Drug Design Targeting Cruzipain

Aiman Parvez Jeong‐Sang Lee Waleed Alam Hilal Tayara Kil To Chong

View Full Paper

Ask AI

Bookmark

Share

Abstract

Cruzipain inhibitors are required after medications to treat Chagas disease because of the need for safer, more effective treatments.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Parvez et al. (2024) studied this question.

synapsesocial.com/papers/68e721fab6db64358769b66a https://doi.org/10.3390/ijms25073747

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical CandidatesReview · 2026
2Using the Scaffold of FDA-Approved Drugs with Trypanocidal Activity to Identify New Anti-Trypanosoma cruzi Agents: An In Silico and In Vitro ApproachOriginal Research · 2026 · 1 citations
3Integrating Molecular Similarity and AlphaFold-Based Structural Alignment for Target Discovery in Trypanosoma cruziOriginal Research · 2026
4Identification of Novel Trypanosoma cruzi Cysteine Protease Inhibitors via Ligand-Based Virtual Screening of FDA-Approved Drugs with Trypanocidal ActivityOriginal Research · 2026
5In Silico Studies and Biological Evaluation of Thiosemicarbazones as Cruzain-Targeting Trypanocidal Agents for Chagas DiseaseOriginal Research · 2026 · 1 citations

More related papers

Structure-Aided Computational Design of Triazole-Based Targeted Covalent Inhibitors of Cruzipain2024
Machine learning, molecular docking and simulation studies reveal Lomitapide, Lodipamide, Zafirlukast, Netupitant and Salmon Calcitonin as potent drug molecules against Chagas disease2024
Identification of Potential Trypanosoma cruzi Trans-Sialidase Inhibitors by Computational Drug Repositioning Approaches2024

More from International Journal of Molecular Sciences

Prometheus’s Fire, Part II: The Hydra of Inflammation—Multiorgan Self-Amplifying Inflammatory Loops in Obesity: Molecular Crosstalk Between Adipose Tissue, Liver, Skeletal Muscle, Pancreas and Cardiovascular SystemWed,
M4-like Macrophages Drive Skeletal Muscle Fibrosis and Suppress Myogenesis via the MMP12/SPP1/NF-κB AxisWed,