Genetic variation in severe cystic fibrosis liver disease is associated with novel mechanisms for disease pathogenesis

Jaclyn R. Stonebraker; Rhonda G. Pace; Paul J. Gallins; Hong Dang; Melis A. Aksit; Anna Faino; William W. Gordon; Sonya A. MacParland; Michael J. Bamshad; Ronald L. Gibson; Garry R. Cutting; Peter R. Durie; Fred A. Wright; Yi‐Hui Zhou; Scott M. Blackman; Wanda K. O’Neal; Simon C. Ling; Michael R. Knowles

doi:10.1097/hep.0000000000000863

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Abstract

It is not known why severe cystic fibrosis (CF) liver disease (CFLD) with portal hypertension occurs in only ~7% of people with CF. We aimed to identify genetic modifiers for severe CFLD to improve understanding of disease mechanisms.

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Stonebraker et al. (2024) studied this question.

synapsesocial.com/papers/68e721fab6db64358769b87f https://doi.org/10.1097/hep.0000000000000863

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Genetic variation in severe cystic fibrosis liver disease is associated with novel mechanisms for disease pathogenesis

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Abstract

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Cite This Study

Genetic variation in severe cystic fibrosis liver disease is associated with novel mechanisms for disease pathogenesis

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Abstract

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