Nose to Brain Drug Delivery System

The treatment of brain disorders is particularly challenging due to the presence of a variety of formidable obstacles to deliver drugs selectively and effectively to the brain. Blood-brainbarrier (BBB) constitutes the major obstacle to the uptake of drugs into the brain following systemic administration. Intranosedelivery offers a non-invasive and convenient method to bypass the BBB and delivery of therapeutics directly to the brain. The review discusses the potential of intranoseroute to deliver drugs to the brain, the mechanisms and pathways of direct nose to brain drug transport, the various factors influencing transnosedrug absorption, the conventional and novel intranosedrug delivery systems, the various intranosedrug delivery techniques and devices, and examples of brain drug transport that have been feasible in treating various brain disorders. Moreover, products on the market, investigational drugs, and the author’s perceptions about the prospect of intranosedelivery for treating brain disorders are also been discussed.