Supplementary Figure S3 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Giorgia Maroni; Indira Krishnan; Roberta Alfieri; Valerie A. Maymi; Nicole Pandell; Eva Csizmadia; Junyan Zhang; Marla Weetall; Art Branstrom; Giulia Braccini; Eva Cabrera San Millán; Barbara Storti; Ranieri Bizzarri; Olivier Kocher; Daniela S. Daniela Sanchez Bassères; Robert S. Welner; Maria Cristina Magli; Ivan Merelli; John G. Clohessy; Azhar Ali; Daniel G. Tenen; Elena Levantini

doi:10.1158/2767-9764.25480975.v1

Key Points

Epithelial cluster deconvolution identifies C0epi and C4epi as distinctly malignant subpopulations within the EGFR-mutant NSCLC cellular landscape.
Analysis of healthy and diseased tissue profiles characterizes cellular differentiation states across epithelial clusters without reported cohort metrics.
Highlights malignant epithelial subsets in tumor microenvironment remodeling under unesbulin treatment; preclinical cell model requires further validation.

Implication

Cellular deconvolution reveals malignant epithelial clusters in EGFR-mutant lung cancer models, indicating distinct tumor microenvironment phenotypes.

Abstract

Supplementary Figure S3. Deconvolution of healthy and diseased epithelial clusters highlights the malignant nature of C0epi and C4epi

Discussion

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Cite This Study

Maroni et al. (2024) studied this question.

synapsesocial.com/papers/68e7263ab6db64358769f977 https://doi.org/10.1158/2767-9764.25480975.v1

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Supplementary Figure S3 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S3 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Key Points

Implication

Abstract

Discussion

Cite This Study

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