In-vitro Evaluation of Antioxidant Activity of Glabridin in Combination with Oroxylin-A

There has been a significant increase in interest in the study of free radicals due to shifting dietary and environmental patterns. Our bodies can become exposed to diverse physiochemical circumstances, pathogenic states, or distinct endogenous systems that produce free radicals. Oxidative stress is a condition caused by the body’s exposure to free radicals. We have to give the body an antioxidant source when it can’t handle more oxidative stress. A material that prevents oxidative damage to a target molecule, which is mostly brought on by free radicals, is referred to be an antioxidant. Antioxidants are essential for treating numerous ailments or are used as a supportive treatment for a wide range of disorders brought on by or made worse by oxidative stress. Glabridin and oroxylin-A are well-known active phytoconstituents with high anti-obesity activity. Antioxidants’ hypolipidemic action and potential are very helpful in the treatment of disorders associated with obesity. The current investigation attempts to assess the antioxidant capacity of both oroxylin-A and glaciridin. Ascorbic acid was utilized as the reference antioxidant agent for comparison while evaluating the antioxidant activity. According to the findings, both active ingredients exhibit substantial antioxidant activity more than 65% greater than regular ascorbic acid. When combined with oroxylin-A, glabridin exhibits even greater antioxidant activity more than 80% higher than that of regular ascorbic acid.