Association of Illegal Behavior with GST Isoforms Null Genotyping in Methamphetamine Abuse Cases

The present study aims to detect the association of illegal behavior with GST isoforms in methamphetamine abuse cases. The present study targeted two GST isoforms included, GSTT1 and GSTM1. The results found a strong association between GSTT1 null genotyping and meth addiction cases (p 0.0078) that were more frequent in cases (46.80%) than the control group (17.24%), non-significant relation was observed between GSTM1 and GSTM1 null genotyping (p = 0.1122). Also, non-significant changes in the genotyping GSTT1 null GSTM1 and GSTM1 null GSTT1, and the normal GSTM1+GSTT1 genotyping with null genotyping of both genes. The distribution of GST null genotyping according to sex found non-significant differences observed between male and females in all genotypes GSTT1 (p = 0.1181), GSTM1 (p = 0.6525), GSTT1 null GSTM1 and GSTM1 null GSTT1 (p = 0.8226), finally GSTT1+GSTM1 with null both genes was (p = 0.158). The null GSTT1 was more frequent in cases without illegal behavior (60.86%) in non-significant differences (p = 0.1125). Null genotyping of GSTM1 more frequent in cases without illegal behavior (43.47%) but didn’t observe in illegal behavior cases in significant differences (p = 0.0143). Non-significant difference was recorded (p = 0.1935) in companies between GSTT1+ GSTM1 null genotyping. Finally, the differences between GSTT1 and GSTM1 and null both genes weren’t observed in cases with illegal behavior than in cases without illegal behavior that recorded in (25%) in significant differences (p = 0.0231). The results concluded that the null genotyping didn’t associate with illegal behavior represented by agitation and agitation with antisocial behavior. Furthermore, there was a strong correlation between meth abuse and GSTT1 null genotyping.