Polymer Complexes of Amikacin with Sulfur-Containing Polymers

Polymer complexes of amikacin based on two sulfonic polymers, dextran sulfonic acid and poly-2-acrylamido-2-methylpropane sulfonic acid, containing 25 and 33 wt % of the antibiotic, respectively, have been synthesized. Molecular weights and limiting binding capacities were determined for carrier polymers. The formation of polymer complexes was confirmed by IR and UV spectroscopy, as well as by GPC. The kinetics of amikacin release from complexes was investigated in water at 37°С. The resulting complexes exhibited high antibacterial activity, close to control, and weak antiviral activity.