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Abstract Background: Role of CTCs in metastatic cancers to predict the % prediction of overall survival has been well-established. The effectiveness of three- or six-months adjuvant therapy in colorectal cancer estimation showed association of CTCs with the emergence of resistant cell clones. The presence of CTCs with clusters indicates an aggressiveness of the epithelial cancers. However, the presence of CTC clusters has not been evaluated in large populations. Here, we demonstrate the distribution prophecy of CTCs and CTC clusters in epithelial cancer patients. Methods: Retrospectively, 3458 patients' blood sample was analyzed for the presence and distribution of CTCs and CTC clusters using DCGI approved OncoDiscover platform having immunomagnetic multicomponent system mediated by anti EpCAM antibody. 1. 5 mL of peripheral blood was analyzed to capture cells and clusters from Head Part 1 (Regular Abstracts) ; 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84 (6Suppl): Abstract nr 7508.
Khandare et al. (2024) studied this question.