Randomized trial finds that high fucosyltransferase 5 expression worsens outcomes in high grade serous ovarian cancer, suggesting new immunotherapy avenues.
Key Points
High fucosyltransferase 5 expression correlates with a significant decrease in double negative T cells, indicating a potential mechanism for immune evasion.
In FUT5high samples, we observed a notable reduction in CD3+CD4−CD8− T cells, emphasizing FUT5's role in tumor immunity.
Analysis using immunohistochemistry and flow cytometry confirmed the modulation of T cell subsets, including CD8+ memory cells and DN T cells in FUT5 knockdown models. This suggests a vital implication for targeted immunotherapy strategies in ovarian cancer treatment.