Immune reconstitution inflammatory syndrome (IRI S) in reproductive health

Pregnancy is a process which generate great immunologic changes with participation of T lymphocytes with inflammatory (Th1/Th17) and anti-inflammatory response (Th2/Treg), with the purpose of maintain the optimum condition and fetal development.In HIV infection this immunological ambient are affected directly due the decrease of T CD4 cells.The use of antiretrovirals (ART) has allowed that women living with HIV can decrease the possibility to infect their newborns with the virus.The pregnancy, autoimmune diseases, and the use of ART are known factors for the progress of immune reconstitution inflammatory syndrome due to the abrupt recovery of immune response.In this review we describe some of these changes during the pregnancy and puerperium without any disease added, furthermore we propose a possible behavior of Th1/Th2 profile in women who live with HIV and receive ART during the first year of postpartum.