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March 20, 2024Gates Open ResearchOpen Access

Nasopharyngeal Dysbiosis Precedes the Development of Lower Respiratory Tract Infections in Young Infants, a Longitudinal Infant Cohort Study

Rotem Lapidot Tyler Faits Arshad Ismail Mushal Allam Zamantungwak Khumalo William MacLeod Geoffrey Kwenda Zachariah Mupila Ruth Nakazwe Daniel Segrè W. Evan Johnson Donald M. Thea Lawrence Mwananyanda Christopher Gill

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Abstract

Infants suffering from lower respiratory tract infections (LRTIs) have distinct nasopharyngeal (NP) microbiome profiles that correlate with severity of disease. Whether these profiles precede the infection or are a consequence of it, is unknown. In order to answer this question, longitudinal studies are needed.

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Cite This Study

Lapidot et al. (2024) studied this question.

synapsesocial.com/papers/68e732bfb6db6435876abe05 https://doi.org/10.12688/gatesopenres.13561.2

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The nasopharyngeal microbiome in South African children with lower respiratory tract infection: a nested case-control study of the Drakenstein Child Health Study2024
2Early nasal microbiota and subsequent respiratory tract infections in infants with cystic fibrosis2024
3Insights into the relationship between nasal bacterial composition and susceptibility to early-life respiratory disease: a pilot observational study.2025
4Early bacterial communities in the lower airways and intestines of caesarean section neonates with respiratory disease2025
5Association of Nasopharyngeal Bacterial Colonization during Upper Respiratory Tract Infection and the Development of Acute Otitis MediaOriginal Research · 2008 · 107 citations

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The association of maternal and infant early gut microbiota with respiratory infections in infants2025
Nasopharyngeal microbiome composition and its clinical correlates in children hospitalized with severe pneumonia in East Africa2025
Characterization of longitudinal nasopharyngeal microbiome patterns in maternally HIV-exposed Zambian infants2024

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