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Abstract Disease diagnosis, prognosis, and therapy choice progressively rely on good-quality DNA for molecular analysis. As tissue processing is routinely performed worldwide with ancient techniques using toxic and DNA-damaging formaldehyde, the quality of DNA isolated from embedded tissues used for diagnostics is poor. We used a novel formalin-free method to process tissues and show that, after 5 years, DNA quality is superior to formalin fixation.
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Hoogland et al. (2024) studied this question.
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