Photothermal therapy of CdTeSe@ZnS quantum dots and their photonic state gain amplification fiber applied to brain gliomas at different stages

Mental nanomaterial-mediated photothermal therapy (PTT) offers a prospective therapeutic strategy for solid tumors. However, its clinical application is limited due to insufficient photothermal conversion efficiency for deep-seated tumor and potential cytotoxic. Few photothermal therapy studies have been reported for tumour cells of different morphologies. In this study, CdTeSe/ZnS quantum dots (QDs) generating photoluminescence at 562 nm and 640 nm under 365 nm excitation are presented. The proliferation activity of RAW264.7 cells phagocytosed QDs exhibited a dose-dependent decline, as expected. In vitro, a liquid core fiber loaded with these QDs was utilized for PTT targeting high-grade and low-grade brain glioma cells. In the culture medium of cultured brain glioma cells, the maximum heat around the QDs-fibers under 365 nm laser excitation reached 64.9℃. High-grade U87 glioma cells treated with PTT displayed greater sensitive towards organelle damage compared to low-grade U251 glioma cells. Notably, U87 cells showed significant induction of apoptosis. Therefore, these findings represent further progress towards the applications of QDs-fibers in human solid tumor treatment.