In silico screening of selective ATP mimicking inhibitors targeting the Plasmodium falciparum Grp94

This is the authors' abstract. We don't add key points for this paper.

parasites export more than 400 proteins to remodel the host cell environment and increase its chances of surviving and reproducing. The endoplasmic reticulum (ER) plays a central role in protein export by facilitating protein sorting and folding. The ER resident member of the Hsp90 family, glucose-regulated protein 94 (Grp94), is a molecular chaperone that facilitates the proper folding of client proteins in the ER lumen. In