Acid-Mediated Domino Cyclization of ortho-Formyl Cinnamate Esters: Synthesis of Substituted Indene/Indane Esters and Indeno[a]indenones

A Bro̷nsted acid-driven protocol to access substituted monoarylindene esters, biarylindane esters, and indeno[a]indenones from simple ortho-formylcinnamate esters and external arenes has been revealed. Remarkably, this single-pot process enabled the construction of two, three, and four new C–C bonds in building monoarylindene esters, biarylindane esters, and indeno[a]indenones, respectively, under metal-free and mild reaction parameters via triggering the inactive cinnamate ester moiety. In addition, the present strategy is investigated with widespread substrate scope.