Discovery of Indazole-Based Selective IRAK4 Inhibitors

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Discovery of IRAK4 Inhibitors <b>BAY1834845</b> (Zabedosertib) and <b>BAY1830839</b>Original Research · 2024 · 37 citations
2. 2The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-<i>N</i>-(6-methylpyrazolo[1,5-<i>a</i>]pyrimidin-3-yl)imidazo[1,2-<i>a</i>]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke2024 · 24 citations
3. 3Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation2024 · 9 citations
4. 4The oral <scp>IRAK4</scp> inhibitors zabedosertib and <scp>BAY1830839</scp> suppress local and systemic immune responses in a randomized trial in healthy male volunteers2024 · 11 citations
5. 5Discovery and characterization of SIM0711, a potent and selective IRAK4 PROTAC with enhanced efficacy and safety 46262025