Inverted InP quantum dots emitting in the NIR-I window (700-900 nm) are promising fluorescent contrast agents for paired-agent imaging (PAI) due to their amenability to size-matching without compromising photoluminescence quantum yield. We present an optimized synthesis that uses drip addition of InP magic sized clusters (MSCs) as single source precursors. This method eliminates pyrophoric precursor from the shelling reaction and significantly reduces reaction time. We then synthesized a size-matched pair of NIR-I emitting inverted InP QDs for two-color PAI and then demonstrated two color NIR-I imaging of this QD pair in liquid phantoms and tumor spheroid models in vitro.
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Patel et al. (2024) studied this question.
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