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There are an expanding number of contrast agents under development in the field of intraoperative fluorescence imaging. We demonstrate solid phantoms focused on addressing clinical and pre-clinical fluorophores while also incorporating tissue-mimicking optical properties. Characterization techniques and design considerations are discussed. Examples of OTL38-equivalent solid reference targets and dynamic flow phantoms are presented. Use cases are used to demonstrate how these tools reduce development time and accelerate the clinical adoption of new fluorescence imaging technologies.
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LaRochelle et al. (2024) studied this question.
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