Anaplasma phagocytophilum is the intracellular bacteria that causes Human Granulocytic Anaplasmosis (HGA). While the skin is known as the entry site for the bacteria, HGA is characterized by systemic infection of A. phagocytophilum, but it is unknown how a localized infection of A. phagocytophilum leads to HGA. Here, we use a multimodal microscopy approach to image collagen and immune cell alterations due to A. phagocytophilum infection. Second-harmonic generation imaging revealed collagen fiber density decreased at the tick bite of infected skin. Additionally, significant differences in autofluorescence lifetime were observed due to A. phagocytophilum infection of human myeloid HL-60 cells.
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Walsh et al. (2024) studied this question.
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