Fourier light field camera array mesoscope for video-rate 3D imaging

We present the Fourier Light field Camera Array Microscope (FL-CAM) for high-throughput, single-snapshot 3D imaging of mesoscale samples, particularly freely moving model organisms. The FL-CAM substitutes the micro-lens array of typical light field systems for a synchronized array of 48 independent imaging systems. The FL-CAM can capture multi-perspective images over a 3.1 cm x 4.1 cm field of view with 38o angular range at up to 200 frames per second and uses a physics-supervised machine learning algorithm, which accounts for the unique distortion patterns created by the cascade of lenses, to achieve 3D visualization.