Stereoselective Synthesis of β, γ‐Fused Bicyclic γ‐Ureasultams via an Intramolecular Mannich and aza‐Michael Addition Cascade

A novel approach has been developed for the synthesis of bicyclic β, γ ‐fused bicyclic γ ‐ureasultams containing two consecutive chiral centers through an intramolecular Mannich and aza‐Michael addition cascade of alkenyl sulfamides. The straightforward practical procedure and readily available starting materials enable the synthesis of variously substituted ureasultams. In addition, bicyclic γ ‐ureasultams is a class of potential biotin analogues.