PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 11, 2024JAMA Neurology84 citationsOpen Access

Clopidogrel Plus Aspirin vs Aspirin Alone in Patients With Acute Mild to Moderate Stroke

View Full Paper
HCHui-Sheng ChenYCYu CuiXWXinhong Wang

Key Points

  • Dual antiplatelet therapy is found to be superior in reducing recurrent strokes, emphasizing its potential utility.
  • A primary endpoint of recurrent strokes was significantly different between dual therapy and single aspirin.
  • Assessment using dual antiplatelet therapy highlights its efficacy in mild to moderate ischemic strokes, although evidence remains limited and inconclusive yet compelling to explore further benefits.  The need for more robust data is apparent as dual therapies could play a crucial role in managing these patients.

Abstract

Dual antiplatelet therapy has been demonstrated to be superior to single antiplatelet in reducing recurrent stroke among patients with transient ischemic attack or minor stroke, but robust evidence for its effect in patients with mild to moderate ischemic stroke is lacking.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Chen et al. (2024) studied this question.

synapsesocial.com/papers/68e747eeb6db6435876c1291https://doi.org/10.1001/jamaneurol.2024.0146
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack2013 · 1,870 citations
  2. 2Risks and benefits of clopidogrel–aspirin in minor stroke or TIA2017 · 63 citations
  3. 3Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA2018 · 1,356 citations
  4. 4Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke2023 · 211 citations
  5. 5Effects of Clopidogrel Added to Aspirin in Patients with Recent Lacunar Stroke2012 · 685 citations