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March 11, 2024DNA and Cell Biology

Tanshinone I Stimulates Pyroptosis of Cisplatin-Resistant Gastric Cancer Cells by Activating the NF-κB/Caspase-3(8)/GSDME Signaling Pathway

Guijun Wang Yanrong Li Zhaokai Guo Qiang He Zhen Liu Bei‐Bei Deng

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Abstract

Cisplatin (DDP) resistance frequently occurs in gastric cancer (GC) therapy. Tanshinone I is a liposoluble phenanthraquinone compound present in the roots of

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Cite This Study

Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e7493fb6db6435876c1ba3 https://doi.org/10.1089/dna.2023.0293

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Tanshinone <scp>IIA</scp> ameliorates cisplatin‐induced toxicology and cisplatin resistance via regulating <scp>SLC7A11</scp> expressionOriginal Research · 2023 · 5 citations
2TRAP1 induced cisplatin resistance in gastric cancer cells by regulating oxidative stress2025
3SIRT3 regulates mitochondrial metabolism through deacetylation of SLC25A6 to impact gastric cancer progression and drug resistanceOriginal Research · 2026 · 1 citations
4Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways2024 · 28 citations
5Dihydrotanshinone I Targets MIF to Inhibit GSK ‐3β/β‐Catenin Axis‐Mediated Invasion and Metastasis in Gastric CancerOriginal Research · 2026

The Zuo Jin Wan Formula Reverses Cisplatin Resistance in Gastric Cancer by Inhibiting the Mitochondrial Translocation of Dynamin‐Related Protein 1 and Its Mediated Mitochondrial Fission and Mitophagy2026
Dihydrotanshinone I inhibits gallbladder cancer growth by targeting the Keap1-Nrf2 signaling pathway and Nrf2 phosphorylation2024
TGF-β1 Promotes the Recovery of Dorsal Root Ganglion Neurons from Cisplatin-Induced Injury Through Smad4-Dependent Mechanism2026
Efficient Generation of Single- and Multigene CRISPR-Cas9 Knockout in Human CellsDNA and Cell Biology · 2026
3D Adipose-Derived Stem Cells to Hepatocyte-Like Cell Scaffold to Investigate the Drug-Induced HepatotoxicityDNA and Cell Biology · 2026

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