Amplification sensing manipulated by a sumanene-based supramolecular polymer as a dynamic allosteric effector

Abstract The synthesis of signal-amplifying chemosensors induced by various triggers is a major challenge for multidisciplinary sciences. In this study, a signal-amplification system that was flexibly manipulated by a dynamic allosteric effector (trigger) was developed. Herein, the focus was on using the behavior of supramolecular polymerization to control the degree of polymerization by changing the concentration of a functional monomer (seed). It was assumed that this control was facilitated by a gradually changing/dynamic allosteric effector. A curved-π buckybowl sumanene and a sumanene-based chemosensor (SC) were employed as the seed/allosteric effector and the molecular binder, respectively. The hetero-supramolecular polymer, (SC•(sumanene)n), facilitated the manipulation of the degree of signal-amplification; this was accomplished by changing the sumanene seed concentration, which resulted in up to a 62.5-fold amplification of a steroid. The current results and the concept proposed herein provide an alternate method to conventional chemosensors and signal-amplification systems.