The Association between Statin Medication Use and Intracranial Aneurysm Risk: A Two- Way Mendelian Randomization Study

Recent observational studies have identifi ed a potential link between statin medication use and the risk of intracranial aneurysms (IAs). However, the causal relationship between these factors is not yet clear.Methods:We used a two-way Mendelian randomization approach to examine the relationship between genetically predicted statin medication use and the risk of IAs, as well as the reverse association. We incorporated data from genome-wide association studies of statin medication and IAs in a European population. Our analysis relied on random-effects inverse variance weighted estimation as the primary statistical method.Results:Neither statin medication use nor IA risk was signifi cantly associated with the other, according to ourfindings. The odds ratio (OR) for statin medication was 1.551 (95% confi dence interval [CI]: 0.895–2.685,P = 0.117), and the OR for IA risk was 1.020 (95% CI: 0.984–1.059, P = 0.281). Our results were consistent across different analytical methods, including MR-Egger regression and weighted median.Conclusions:These fi ndings suggest that there is no causal relationship between statin medication use and IA risk.