Anti-integrin αvβ6 autoantibodies are a potential biomarker for ulcerative colitis-like immune checkpoint inhibitor-induced colitis

Masataka Yokode; Masahiro Shiokawa; Hisato Kawakami; Takeshi Kuwada; Yoshihiro Nishikawa; Yuya Muramoto; Hiroki Kitamoto; Makoto Okabe; Hajime Yamazaki; Norihiro Okamoto; Toshihiro Morita; Kazuya Ohno; Risa Nakanishi; Ikuhisa Takimoto; Muneji Yasuda; Koki Chikugo; Shimpei Matsumoto; Hiroyuki Yoshida; Sakiko Ota; T Nakamura; Hirokazu Okada; Tomonori Hirano; Nobuyuki Kakiuchi; Tomoaki Matsumori; Shuji Yamamoto; Norimitsu Uza; Makoto Ooi; Yuzo Kodama; Tsutomu Chiba; Hidetoshi Hayashi; Hiroshi Seno

doi:10.1038/s41416-024-02647-1

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Abstract

No specific biomarker for immune checkpoint inhibitor (ICI)-induced colitis has been established. Previously, we identified anti-integrin αvβ6 autoantibodies in >90% of patients with ulcerative colitis (UC). Given that a subset of ICI-induced colitis is similar to UC, we aimed to clarify the relationship between such autoantibodies and ICI-induced colitis.

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Yokode et al. (2024) studied this question.

synapsesocial.com/papers/68e74cd0b6db6435876c55f8 https://doi.org/10.1038/s41416-024-02647-1

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Anti-integrin αvβ6 autoantibodies are a potential biomarker for ulcerative colitis-like immune checkpoint inhibitor-induced colitis

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Abstract

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Cite This Study

Anti-integrin αvβ6 autoantibodies are a potential biomarker for ulcerative colitis-like immune checkpoint inhibitor-induced colitis

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Abstract

Discussion

Cite This Study

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