Synthesis, spectral, anti-diabetic, anti-inflammatory, antioxidant, and molecular docking investigations of acridine derivatives

Every synthesised molecule was assessed for IR, 1 H, 13 C NMR, and mass spectral analysis approaches to validate the new acridine derivatives we synthesized for this work's conventional method. Biological studies like anti-inflammatory and anti-oxidant activities with DPPH radical scavenging activity, anti-diabetic properties, and molecular docking were examined. The anti-diabetic properties of acridine derivatives indicate that compounds 2 and 7 exhibit greater activity compared to the typical acarbose one, with IC50 values of 26 and 25, respectively. According to in-vitro investigations on anti-inflammatory effect, compounds 4 and 6 have larger inhibition percentages than the other compounds. The oxidoreductase tuberculosis protein is tightly docked with the synthesised moieties. Compound 7 exhibits the highest inhibition constant of 608.73 µM.