Research progress and future development direction of Alzheimer's therapy

Dementia has become a global crisis, numbering over 50 million people in the world, more than half of whom are Alzheimers disease (AD)s patients. AD is a heterogeneous disease that has complex pathobiologic properties. The exact AD mechanism is unclear at this point, but the pathological hallmarks constitute amyloid- (A) plaques and tau neurofibrillary tangles and most treatments are based on this. AD has a serious impact on society and on humanity, but drugs approved to treat AD are few and ineffective. The article analyzes the possible causes of pathological hallmarks and describes existing treatment options, as well as their shortcomings and potential future treatments. It also speculates on the direction of possible future therapeutic options providing reference for more new technologies and methods of treating AD in the future. However, there are still many unclear pathogenic mechanisms and more effective treatments are needed for further research on AD in the future.