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Abstract Diabetes mellitus (DM) is a metabolic condition that resulted from an imbalance in insulin production or function. Nonetheless, research has proved traditionally that medicinal plants with antidiabetic activities may provide valuable information for the development of safer and more potent oral hypoglycemic medications. The study therefore investigated the effects of aqueous extract of Chrysophyllum albidum seed on the pancreas and kidney of hyperglycemic Wistar rats. Forty male Wistar rats weighing between 90g-150g were divided into four groups (n = 10). Group 1 (control) received 2 ml of distilled water; Group 2 and 3 (diabetic) injected intraperitoneally with a single dose of 50 mg/kg of streptozotocin (STZ) after 12hrs fasting period. Group 3 (diabetic treated) treated with 750 mg/kg aqueos extract of Chrysophyllum albidum seed, Group 4 (normoglycemic) treated with 750 mg/Kg of the extract. The tissue samples were stained with hematoxylin and eosin (H & E) routine staining, Gomori and Masson trichome special staining to demonstrate the histoarchitecture of the tissue samples. The results showed a significance reduction (p Chrysophylum albidum seed has anti-diabetic properties with significant reduction in blood glucose level in the hyperglycemic Wistar rats. Further studies of the mechanism involved and screening of bioactive components of the extracts are recommended.
OLANIYI et al. (Thu,) studied this question.
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