Separation of OH-containing compounds from the essential oil mixture via a one-pot synthesis of carbamates, antimicrobial evaluation and dynamic 1H NMR study of their derivatives

A series of various carbamate derivatives were synthesized using essential oils of various plants and cyclohexyl or phenyl isocyanate under solvent-free conditions. Carvacrol , Thymol and Eugenol were chosen for synthesis that exist in Satureja bachtiarica Bunge , Satureja hortensis L ., Trachyspermum ammi and Caryophyllus aromaticus , respectively. Essential oils after extraction and identification by GC-MS, were used as raw material for synthesis of carbamate derivatives. Antimicrobial activity of synthesized compounds was examined against four Gram-negative and Gram-positive bacteria as well as three fungal strains. Good inhibitory activities were observed with synthesized compounds. Also 1 H NMR dynamic of synthetic carbamates were investigated for this compounds.